4.8 Article

Ultrafast reversible photo-cross-linking reaction: Toward in situ DNA manipulation

Journal

ORGANIC LETTERS
Volume 10, Issue 15, Pages 3227-3230

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801112j

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We describe a novel ultrafast reversible DNA interstrand photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside ((CNV)K). Oligodeoxynucleotide (ODN) containing (CNV)K can be photo-cross-linked by irradiation at 366 nm for 1s, and the photo-cross-linked ODN can be split by irradiation at 312 nm for 60 s.

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