4.8 Article

Copper-catalyzed coupling of hydroxylamines with aryl iodides

Journal

ORGANIC LETTERS
Volume 10, Issue 5, Pages 797-800

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol7029273

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Funding

  1. Engineering and Physical Sciences Research Council [EP/E020607/1] Funding Source: researchfish
  2. EPSRC [EP/E020607/1] Funding Source: UKRI

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An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of M and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.

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