4.8 Article

Dimethyl sulfide induced [3+2] annulation strategy: An efficient synthesis of functionalized dihydropyrazole derivatives using the Baylis-Hillman bromides

Journal

ORGANIC LETTERS
Volume 10, Issue 9, Pages 1819-1821

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800424v

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Baylis - Hillman bromides have been successfully employed as a valuable source of 1,3-dipoles for cycloaddition onto dialkyl azodicarboxylates (dipolarophiles) under the influence of dimethyl sulfide and potassium carbonate to provide functionalized dihydropyrazole derivatives in a simple one-pot [3 + 2] annulation strategy.

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