Journal
ORGANIC LETTERS
Volume 10, Issue 7, Pages 1445-1448Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8002223
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Highly enantioselective synthesis of tetra hydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.
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