4.8 Article

Axial 4,4′,6,6′-Tetrakis-trifluoromethyl-biphenyl-2,2′-diamine (TF-BIPHAM): Resolution and Applications in Asymmetric Hydrogenation

Journal

ORGANIC LETTERS
Volume 10, Issue 21, Pages 4711-4714

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol8018677

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Funding

  1. National Natural Science Foundation of China [20642005, 20702039]
  2. Wuhan University

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The racemic TF-BIPHAM was resolved for the first time, and the effectiveness of the resolved diamine was demonstrated by highly enantioselective hydrogenation of alpha-aryl enamides and (x-dehydroamino acid esters using readily accessible bis(aminophosphine) ligands.

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