Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides

A wide variety of alkoxymethyltrifluoroborate substrates were prepared via S(N)2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.