Journal
ORGANIC LETTERS
Volume 10, Issue 2, Pages 205-208Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol702521g
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A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The results confirm the versatility and efficiency of the method for the preparation of cyclic oligopeptoids.
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