4.8 Article

Direct access to anthranilic acid derivatives via CO2 incorporation reaction using arynes

Journal

ORGANIC LETTERS
Volume 10, Issue 17, Pages 3845-3847

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801588s

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Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology, Japan [19750080]
  2. Grants-in-Aid for Scientific Research [19750080] Funding Source: KAKEN

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CO2 was found to be directly convertible into anthranilic acid derivatives of great synthetic value through a three-component coupling using arynes and amines. Zwitterions arising from nucleophilic attack of amines to arynes serve as key intermediates in the coupling.

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