4.8 Article

Total synthesis of a marine alkaloid from the tunicate Dendrodoa grossularia

Journal

ORGANIC LETTERS
Volume 10, Issue 17, Pages 3737-3739

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801375k

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Funding

  1. American Cancer Society [RSG CDD-106972]
  2. Michigan State University

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A short synthesis of an indole marine alkaloid (1) from the tunicate Dendrodoa grossularia is described. The key step in the synthesis involves a novel twist on an underutilized oxazole rearrangement, which produces the quaternary stereocenter in the molecule.

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