4.8 Article

Copper-catalyzed sonogashira-type reactions under mild palladium-free conditions

Journal

ORGANIC LETTERS
Volume 10, Issue 15, Pages 3203-3206

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801025u

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We have developed an inexpensive catalytic system using a readily available copper/ligand combination for the Sonogashira-type cross-coupling of aryl iodides and phenyl- and hexyl-acetylene which affords disubstituted alkynes in good to excellent yields.

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