Journal
ORGANIC LETTERS
Volume 10, Issue 8, Pages 1577-1580Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol800256j
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- NIGMS NIH HHS [P50 GM 69721] Funding Source: Medline
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The regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest to excellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetic transformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.
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