Regio- and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl•LiCl

Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl center dot LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported.