Journal
THROMBOSIS AND HAEMOSTASIS
Volume 114, Issue 2, Pages 228-236Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH14-11-0962
Keywords
Platelet; microvesicle; microparticle; vascular inflammation; atherosclerosis
Categories
Funding
- Deutsche Forschungsgemeinschaft [DFG Ko2948/1-2, SFB1123/1 A02, FOR809]
- Netherlands Foundation for Scientific Research [ZonMW VIDI 016.126.358]
Ask authors/readers for more resources
Microvesicles are receiving increased attention not only as biomarkers but also as mediators of cell communication and as integral effectors of disease. Platelets present a major source of microvesicles and release these microvesicles either spontaneously or upon activation. Platelet-derived microvesicles retain many features of their parent cells and have been shown to exert modulatory effects on vascular and immune cells. Accordingly, microvesicles from platelets can be measured at increased levels in patients with cardiovascular disease or individuals at risk. In addition, isolated microvesicles from platelets were shown to exert immunomodulatory actions on various cell types. In this review the various aspects of platelet-derived microvesicles including release, clearance, measurement, occurrence during disease and relevance for the pathophysiology of vascular inflammation will be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available