Journal
THROMBOSIS AND HAEMOSTASIS
Volume 113, Issue 3, Pages 494-504Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH14-07-0603
Keywords
Cardiovascular; heart; oxidative stress; selenium; selenoproteins
Categories
Funding
- NIH [P20RR016453, AI089999]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016453] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI089999, R01AI089999] Funding Source: NIH RePORTER
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Dietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others. In this review, we summarise the current understanding of the roles these selenoproteins play in protecting the cardiovascular system from different types of stress including ischaemia-reperfusion, homocysteine dysregulation, myocardial hypertrophy, doxirubicin toxicity, Keshan disease, and others.
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