Journal
THORAX
Volume 71, Issue -, Pages 1-22Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2015-207360
Keywords
Cystic Fibrosis; Bacterial Infection
Categories
Funding
- Cystic Fibrosis Foundation
- European Cystic Fibrosis Society
- Wellcome Trust
- Cambridge NIHR BRC
- Intramural programme of the National Heart, Lung, and Blood Institute, NIH
- Vaincre La Mucoviscidose [VLMIC1014, RF20120600689]
- Region Ile-de-France Domaine d'Interet Majeur Maladies Infectieuses et Emergentes
- CF Foundation Clinical Research Award [NICK13A0]
- Imperial College London NIHR Respiratory BRU
- Cystic Fibrosis Trust [VIA025] Funding Source: researchfish
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL006200] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). Pulmonary disease caused by NTM has emerged as a major threat to the health of individuals with CF but remains difficult to diagnose and problematic to treat. In response to this challenge, the US Cystic Fibrosis Foundation (CFF) and the European Cystic Fibrosis Society (ECFS) convened an expert panel of specialists to develop consensus recommendations for the screening, investigation, diagnosis and management of NTM pulmonary disease in individuals with CF. Nineteen experts were invited to participate in the recommendation development process. Population, Intervention, Comparison, Outcome (PICO) methodology and systematic literature reviews were employed to inform draft recommendations. An anonymous voting process was used by the committee to reach consensus. All committee members were asked to rate each statement on a scale of: 0, completely disagree, to 9, completely agree; with 80% or more of scores between 7 and 9 being considered good' agreement. Additionally, the committee solicited feedback from the CF communities in the USA and Europe and considered the feedback in the development of the final recommendation statements. Three rounds of voting were conducted to achieve 80% consensus for each recommendation statement. Through this process, we have generated a series of pragmatic, evidence-based recommendations for the screening, investigation, diagnosis and treatment of NTM infection in individuals with CF as an initial step in optimising management for this challenging condition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available