4.6 Article

Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 39, Pages 7109-7114

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02012d

Keywords

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Funding

  1. National Natural Science Foundation of China [21702117, 21776148]
  2. Natural Science Foundation of Shandong Province [ZR2017BB005, ZR2016BM07]
  3. Key Research & Development Program of Shandong Province [2018GSF118224]
  4. Qingdao Special Research Foundation of Science and Technology [16-6-2-29-nsh]
  5. Talents of High Level Scientific Research Foundation of Qingdao Agricultural University [6631115015, 6631110309]

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An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.

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