Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 39, Pages 7109-7114Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02012d
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Funding
- National Natural Science Foundation of China [21702117, 21776148]
- Natural Science Foundation of Shandong Province [ZR2017BB005, ZR2016BM07]
- Key Research & Development Program of Shandong Province [2018GSF118224]
- Qingdao Special Research Foundation of Science and Technology [16-6-2-29-nsh]
- Talents of High Level Scientific Research Foundation of Qingdao Agricultural University [6631115015, 6631110309]
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An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.
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