Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 33, Pages 6025-6034Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob01493k
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Funding
- National Natural Science Foundation of China [U1504206]
- Foundation of He'nan Educational Committee [18A150002]
- Henan University [yqpy20170008]
- Kaifeng City
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An efficient three-component one-pot [3 + 2] cycloaddition of isatins, 1,2,3,4-tetrahydroisoquinolines and methyleneindolinones has been developed. This reaction proceeded in a highly diastereoselective manner to afford a wide range of pyrrolo[1,2-a]isoquinoline-based bispirooxindoles in up to 91% yields. Additionally, a gram-scale experiment and some chemical transformations were conducted.
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