4.6 Article

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 27, Pages 4828-4831

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00970c

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Funding

  1. Marine Alliance for Science and Technology for Scotland (MASTS) [SG183]
  2. EPSRC [EP/I034734/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/I034734/1] Funding Source: researchfish

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Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluoro-metabolite producing microorganism identified from the marine environment.

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