Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 32, Pages 6190-6199Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01088d
Keywords
-
Categories
Funding
- Welch Foundation [AX-1788]
- National Institute of General Medical Sciences [SC3GM105579]
- Max and Minnie Tomerlin Voelcker Fund
- NIH MBRS-RISE [GM060655]
- University of Texas at San Antonio
- National Institute on Minority Health and Health Disparities [G12MD007591]
Ask authors/readers for more resources
The scope. and mechanistic implications of the direct transformation of heterocyclic N-oxides to 2-trifluoromethyl-, and related perfluoroalkyl- and perfluoroaryl-substituted N-heterocycles has been studied. The reaction is effected by perfluoroalkyl- and perfluorophenyltrimethylsilane in the presence of strong base. In situ displacement of the para-fluoro substituent in the pentafluorophenyl ring and the methoxy group in 8-methoxyquinolines with additional nucleophiles allows for further site-selective refunctionalization of the N-heterocyclic products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available