Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 45, Pages 9101-9104Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01902d
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Funding
- Key Research Foundation of the Education Department of Henan Province [14A150029]
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A highly enantioselective direct Mannich reaction of methyl alkyl ketones with cyclic imines benzo[e][1,2,3] oxathiazine 2,2-dioxides, catalyzed by the combination of cinchona alkaloid derived primary amine and TFA, is disclosed. For unsymmetrical methyl alkyl ketones, it is favoured that specific regioselective addition to the imine substrates occurs at the less-substituted methyl group by steric control.
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