Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 8, Pages 1258-1264Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob42403k
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Funding
- Spanish Ministry of Economia y Competitividad [MEC CTQ2010-19606, CTQ2011-27593]
- Government of Aragon (Zaragoza, Spain Research Group) [E-10]
- Ramon y Cajal program (MEC)
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We report our results concerning the first squaramide-catalysed hydrophosphonylation of aldehydes. In all cases, the reactions proceeded smoothly and cleanly under mild reaction conditions rendering final alpha-hydroxy phosphonates in very good yields and high enantioselectivities. It is one of the few organocatalytic examples of this reaction using aldehydes. It is the first time that diphenylphosphite (1e) has been successfully employed in a chiral Pudovik reaction with aldehydes, in contrast to the dialkylphosphites used in previously published procedures, extending the generality of this asymmetric methodology.
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