Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 38, Pages 7561-7571Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01412j
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Funding
- Health Research Board
- University College Dublin
- Irish Research Council for Science Engineering and Technology (IRCSET)
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An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the epsilon-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.
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