Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 33, Pages 6457-6464Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01260g
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Health Sciences Research Grants for Research on Psychiatric and Neurological Diseases and Mental Health from the Ministry of Health, Labor and Welfare of Japan
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [24550184, 26810086, 25288074] Funding Source: KAKEN
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2'-O-Methyl oligoribonucleotides with four kinds of 2'-O-modified uridine derivatives were synthesised. Their duplex stability, hydration behavior and exonuclease resistance were studied by spectroscopic analyses and molecular dynamics simulations. Consequently, 2'-O-modification of the uridine residue with 2-carbamoylethyl or 2-(N-methylcarbamoyl)ethyl groups resulted in a significant improvement of the exonuclease resistance without the loss of duplex stability.
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