Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 30, Pages 5563-5573Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00827h
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- National Tsing Hua University
- Ministry of Science and Technology of Taiwan
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Carbohydrates are essential mediators of many important extracellular binding events. Multivalent effects are often required for these binding interactions that are generally weak. Biologically significant carbohydrate-modified nanomaterials are an appealing model system for a systematic investigation of multivalent binding effects. This review seeks to highlight recent striking examples of multivalent glycosylated nanomaterials concentrating on carbohydrate-protein interactions. The specific aim is to provide an overview of various aspects of glyco-nanoparticles in binding assays, targeted therapy, molecular imaging, enzyme activity assay, and bacterium detection.
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