Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 21, Pages 3441-3445Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00214h
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Funding
- National Program on Key Basic Research Project [2012CB524906]
- National Natural Science Foundation of China [81125023]
- Shanghai Commission of Science and Technology [13DZ2290300]
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A series of structurally related analogues of the natural product paracaseolide A were synthesized and identified as potent PTP1B inhibitors. Among these analogues, compound 10 in particular showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
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