4.6 Article

Copper-catalyzed redox-neutral C-H amination with amidoximes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 1, Pages 42-46

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41871e

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Funding

  1. Nanyang Technological University
  2. Singapore Ministry of Education [MOE2012-T2-1-014]

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Cul-catalyzed reactions of N-alkylamidoximes afforded dihydroimidazoles via sp(3) C-H amination. On the other hand, the reactions of N-benzoylamidoximes resulted in sp(2) C-H amination to form quinazolinones. The reaction mechanisms could be characterized as a redox-neutral radical pathway including a Cu(I)-Cu(II) redox catalytic cycle.

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