4.6 Article

Dual-color imaging of cytosolic and mitochondrial zinc ions in live tissues with two-photon fluorescent probes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 21, Pages 3406-3412

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00101j

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Funding

  1. Korea University
  2. National Research Foundation (NRF) [NRF2012007850]
  3. Basic Science Research Program of the NRF - Ministry of Education [NRF20100020209]
  4. Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A111182]

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We report two-photon probes for Zn2+ ions that can simultaneously detect cytosolic and mitochondrial Zn2+ ions in live cells and living tissues at 115 mm depth by dual-color TPM imaging with minimum interference from other biologically relevant species.

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