Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 13, Pages 2037-2040Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob42453g
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Funding
- National Science Foundation of China [21272087, 21202053, 21232003]
- National Basic Research Program of China [2011CB808603]
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Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp(3) C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).
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