Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 24, Pages 4243-4251Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00475b
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Funding
- Natural Science Foundation of China [21172162, 21372174]
- Young National Natural Science Foundation of China [21202113]
- Key Laboratory of Organic Synthesis of Jiangsu Province [KJS1211]
- PAPD
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201207]
- Soochow University
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A transition-metal-free process for the synthesis of 1,4-dihydroquinoline derivatives starting from simple enaminones with aldehydes via intermolecular cascade cyclization in a one-pot protocol is developed. This methodology affords a variety of products in moderate to good yields. Particularly, the use of the enaminone fragment in 1,4-dihydroquinoline derivatives 3 as a leaving group for further diverse applications with C-nucleophiles is proved to be feasible.
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