4.6 Article

A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 24, Pages 4084-4088

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00652f

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Funding

  1. National Natural Science Foundation of China [21172023]
  2. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
  3. Science & Technology Agency of Jiangsu Province [BY2012096]

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A palladium-catalyzed cascade reaction of N-H insertion (NHI) and oxidative dehydrogenative aromatization (ODA) has been developed, which affords a straightforward and efficient way to access the carbazole precursors (2-arylamino-phenols) as well as to prepare 2-alkylamino-phenols from non-aromatic substrates.

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