Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 29, Pages 5393-5399Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00584h
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21202084, 21372120]
- Tianjin Natural Science Foundation of China [12JCQNJC03500]
Ask authors/readers for more resources
A novel type of transformation was discovered serendipitously during the Barbier-type allenylation reaction of aromatic ketones promoted by the metal, tin, in aqueous media. Additionally, a series of new, highly functionalized 2-bromo-4-aryl-1,3-pentadienes could be obtained with good yields in this reaction. This cascade reaction shows the unique properties of the metal, tin. Furthermore, it is actually a cascade reaction which involves two steps: one is the Barbier-type allenylation of the carbonyl compound, and the other is an S(N)2' type addition-elimination reaction. Notably, this reaction has the advantages of simple, mild conditions and is easy to operate. Furthermore, the corresponding product could be applied to various coupling reactions or other diversified transformations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available