Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 35, Pages 6837-6841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob01031k
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Funding
- National Science Foundation of China [21375113]
- Program for New Century Excellent Talents in University [NCET-11-0950]
- NIH [R01GM088226]
- CSC for Graduate Student Overseas Study Program [201307040059]
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Three sulfonyl benzothiazole-based fluorescent probes (RSHP1, RSHP2, and RSHP3) for the detection of biothiols (cysteine, homocysteine, and glutathione) are developed based on thiol-mediated nucleophilic aromatic substitutions. The probes exhibited good selectivity and sensitivity toward biothiols over other analytes. The probes were successfully applied for visualizing endogenous thiols in living cells.
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