Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 11, Pages 1771-1778Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob42341g
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- Consejeria de Educacion de la Junta de Castilla y Leon [BU340U13]
- Fundacio la Maraton de TV3
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Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50 values in the low micromolar range as well as modify the intracellular pH, inducing the basification of acidic organelles.
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