4.6 Article

The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 22, Pages 3586-3589

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob00487f

Keywords

-

Funding

  1. Deutsche Forschungsgemeinschaft (DFG), KIT
  2. Thailand Research Fund [DPG5780002]
  3. Karlsruhe House of Young Scientists (KHYS)
  4. Alexander von Humboldt Foundation

Ask authors/readers for more resources

Pyrrolidinyl PNA was immobilized on FexOy magnetic particles and was able to capture and thereby discriminate single base alterations in DNA counterstrands better than DNA. The selectivities of matched vs. mismatched oligonucleotides measured by the absorption differences were up to 10-12 which are remarkable values for linear probes.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available