4.6 Article

NBS mediated nitriles synthesis through C=C double bond cleavage

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 12, Issue 8, Pages 1198-1202

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob42118j

Keywords

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Funding

  1. National Science Foundation of China [21172006]
  2. Ph.D. Programs Foundation of the Ministry of Education of China [20120001110013]

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An NBS mediated nitriles synthesis through C=C double bond cleavage has been developed. TMSN3 was employed as the nitrogen source for this Cu(OAc)(2) promoted nitrogenation reaction. This transformation has a relatively high regio-selectivity to form aromatic nitriles.

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