Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 11, Pages 1867-1873Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27433k
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Funding
- National Science Foundation of China [21172092]
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An efficient and direct use of formamides as amino group sources for the synthesis of alpha-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of aceto-phenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I-2/PhCO2H.
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