4.6 Article

An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 1, Pages 44-47

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26943k

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Funding

  1. National Science Council of the Republic of China [NSC 99-2119-M-003-004-MY2]
  2. National Taiwan Normal University [NTNU100-D-06]

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An organocatalytic asymmetric synthesis of spironitrocyclopropanes has been demonstrated starting from 2-arylidene-1,3-indandiones and bromonitroalkanes catalyzed by a cinchona-derived bifunctional organocatalyst. The products were obtained with excellent enantioselectivities, diastereoselectivities and with good yields.

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