Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 2, Pages 378-382Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26564h
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Funding
- Program for New Century Excellent Talents in University [NCET-11-0306]
- Shandong Natural Science Foundation [JQ201019]
- Independent Innovation Foundation of Shandong University, IIFSDU [2010JQ005]
- Graduate Independent Innovation Foundation of Shandong University, GIIFSDU [yzc12096]
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In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. As a result, these molecules were successfully identified as the first ratiometric fluorescent probes for APN cell imaging.
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