Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 4, Pages 555-558Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26911b
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Funding
- National Science Foundation of China [21136002, 21076032, 20923006]
- National Basic Research Program of China [2009CB724706]
- Ministry of Education of China (the Fundamental Research Funds for the Central Universities) [DUT10LK05, DUT10ZD114]
- Scientific Research Fund of Liaoning Provincial Education Department [LS2010040]
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A BODIPY-based dye, OBEP, has been developed to act as a mitochondrial fluorescence probe. This dye is of high stability, low toxicity and insensitive in a pH range as wide as pH 2-10. Its uptake into mitochondria is independent of mitochondrial membrane potential in living cells. OBEP can label swollen mitochondria resulting from different degrees of cell damage in light and resist fading even after 12 h of incubation.
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