Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 42, Pages 7289-7296Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41572d
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Funding
- Singapore National Research Foundation [R279-000-390-281]
- MIT Alliance for Research and Technology (SMART) [R279-000-378-592]
- JCO [IMRE/12-8P1103]
- Hong Kong [HKUST2/CRF/10, AoE/P-03/08]
- Guangdong Innovative Research Team Program [201101C0105067115]
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In this paper, a new live-cell permeable, fluorescent light-up probe comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide and a hydrophobic tetraphenylethene pyridinium unit has been developed for in vivo cell apoptosis imaging and drug screening. The probe shows a specific light-up response to activated caspase-3/7 with a high signal-to-background ratio. The significant fluorescence turn-on response of the probe is due to the aggregation of cleaved hydrophobic residues that populate the radiative decay channels. With good water solubility and biocornpatibility, the probe is demonstrated to be a promising candidate for in vivo real time monitoring of caspase activation and in situ screening of apoptosis-inducing drugs.
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