4.6 Article

A colorimetric and fluorometric BODIPY probe for rapid, selective detection of H2S and its application in live cell imaging

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 47, Pages 8166-8170

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41884g

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Funding

  1. DAE [2010/20/37C/6/BRNS/2480]
  2. DST-SERB [SR/S1/OC-65/2012]
  3. CSIR
  4. UGC
  5. IISER Pune

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A BODIPY-azide based colorimetric and fluorescence turn-ON probe for rapid, selective and sensitive detection of H2S is reported. The probe displayed a fast response time (10 min in HEPES and 30 s in serum albumin), 28-fold fluorescence enhancement and low detection limit up to 259 nM. The application of the probe to the estimation of H2S in live cells was demonstrated.

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