Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 28, Pages 4573-4576Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40787j
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Funding
- National Natural Science Foundation of China [21102110, 21102111]
- Doctoral Fund of the Ministry of Education of China [20110201120076]
- Fundamental Research Funds of the Central Universities
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A copper-catalyzed coupling of alpha-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of alpha-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and C-13-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF.
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