Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 34, Pages 5634-5641Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41028e
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Funding
- National Natural Science Foundation of China [21172112, 21172118]
- National Basic Research Program of China (973 Program) [2010CB833300, 2012CB821600]
- State Key Laboratory on Elemento-organic Chemistry (Nankai University, China)
- Program for New Century Excelent Talents in University [NCET-12-0279]
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The N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals via homoenolate intermediates is described. The reaction provided a direct and efficient method for the synthesis of spiro-bis-lactones. The ketone-carbonyl group annulated products and the ester-carbonyl group annulated products can be obtained as major products with good yields by convenient catalyst regulation. Furthermore, commercially available thiazolium salt can also catalyze this reaction with modest yield.
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