Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 41, Pages 7123-7128Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41566j
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Funding
- National Natural Science Foundation of China [21172110, 21121002]
- Synergetic Innovation Center of Chemical Science and Engineering (Tianjin)
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The reagent system of I-2/K2CO3 could efficiently promote the oxazole synthesis from alpha-bromoketones and benzylamine derivatives in DMF. This method was not only suitable for 2,5-diaryl oxazole synthesis but also for 2,4,5-trisubstituted oxazole and 5-alkyl/alkenyl oxazole synthesis. Furthermore, this method was successfully applied to a one-step synthesis of a natural product halfordinol in 62% yield.
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