4.6 Article

N-Heterocyclic carbene-catalyzed highly enantioselective synthesis of substituted dihydropyranopyrazolones

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 37, Pages 6255-6257

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41455h

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Funding

  1. National Natural Science Foundation of China [21072195]
  2. Ministry of Science and Technology of China [2011CB808600]

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Highly optically pure multisubstituted dihydropyrano[2,3-c]pyrazol-6-(1H)-ones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of alpha-chloroaldehydes and pyrazolone-derived oxodienes.

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