4.6 Article

Bu4NI-catalyzed decarboxylative acyloxylation of an sp3 C-H bond adjacent to a heteroatom with α-oxocarboxylic acids

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 26, Pages 4308-4311

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40748a

Keywords

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Funding

  1. National Natural Science Foundation of China [21102110, 21102111]
  2. Doctoral Fund of the Ministry of Education of China [20110201120076]
  3. Fundamental Research Funds of the Central Universities

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A novel metal-free decarboxylative acyloxylation of an sp(3) C-H bond in formamides and ethers has been explored. A variety of N-acyloxymethylamides and a-acyloxy ethers could be easily synthesized by this method. Preliminary mechanistic studies have shown that the reaction proceeded via a radical process.

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