Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 16, Pages 2724-2727Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27478k
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- RMIT University - School of Applied Sciences
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The total synthesis of a methylated analogue of (+)-Salvianolic acid C has been achieved. Key aspects of the synthetic route include an economical Cu(I) acetylide coupling, unique carboxyl activation conditions via microwave irradiation and a novel lipase catalysed kinetic resolution of a racemic mixture of secondary alcohol Danshensu. The preparation of this methylated analogue will not only improve the bioavailability, but also enable access to new and wider bioactivity applications for (+)-Salvianolic acid C.
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