4.6 Article

Palladium(II)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 16, Pages 2582-2585

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40103k

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Funding

  1. Interdisciplinary Cooperation Team Program for Science and Technology Innovation of the Chinese Academy of Sciences
  2. National Natural Science Foundation of China [21072205, SIMM1203ZZ-0103]

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A one-pot two-step synthesis of versatile indenones has been developed. This palladium(II)-catalyzed transformation involves generation and condensation of ortho-functionalized 1,2-benzils from 2-(2-arylethynylphenyl)acetonitriles using Ph2SO as the oxidant. The resulting 3-cyanoindenones can be converted to various valuable molecules.

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