Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 10, Pages 1650-1658Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27261c
Keywords
-
Categories
Funding
- Association Francaise contre les Myopathies (AFM, Evry, France)
- Association de Transfusion Sanguine et de Biogenetique Gaetan Saleun (Brest, France)
- Conseil Regional de Bretagne
- Brest Metropole Oceane
Ask authors/readers for more resources
Lipophosphoramidates have previously been identified as efficient vectors for gene delivery. The incorporation of functional groups that respond to a physiological stimulus is hypothesised to further improve the efficacy of this type of vector and eventually reduce its cytotoxicity. In the present work, we report the effects of the incorporation of two disulfide motifs into the hydrophobic domain, close to the phosphoramidate group. Three cationic vectors possessing such a red/ox sensitive function were synthesised. The capability of one of them (5b) to compact DNA is reported jointly with its ability to release that DNA in the presence of a reducing agent. Finally, compound 5b was tested as a vector for gene delivery into human cells in vitro and its cytotoxicity was also evaluated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available