Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 9, Pages 1563-1569Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27405e
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Funding
- DST [SR/S1/IC-20/2011]
- CSIR, New Delhi, India [01(2490)/11/EMR-II]
- UGC (UGC-NET)
- DST, PURSE Program, Govt. of India
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A 7-nitrobenz-2-oxa-1,3-diazole (NBD) derived turn-on fluorescent probe (1) exhibits a reversible binding to Cu2+ ion in presence of other metal ions, giving similar to 20 fold increase in fluorescence intensity. The apparent association constant (K-a) for Cu2+ was found to be 2.62 x 10(4) M-1. The intracellular Cu2+ imaging behaviour of chemosensor 1 on HeLa cells studied by fluorescence microscopy revealed that after incubation with 1 cells exhibited intensive fluorescence when exogenous Cu2+ was introduced into the cell. Thus this probe features the ready availability, high sensitivity and selectivity towards Cu2+ in MeCN-H2O (1 : 1, v/v) with cell imaging possibilities with no or negligible cytotoxicity.
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